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Ministry of Health and National Research Foundation of Singapore


Catalyst Awardee

Deciphering Aging-Dependent Human Neuronal Activity Changes, Tissue Microenvironment and Gene Expression Patterns

Jai S. Polepalli, M.A.S., Ph.D., National University of Singapore; Thameem Dheen, Ph.D., National University of Singapore; Vincent Nga Diong Weng, M.B.B.S., M.R.C.S., F.R.C.S.Ed (Surgical Neurology), National University Hospital; and Yeo Tseng Tsai, M.B.B.S., Fellowship of Royal Australasian College of Surgeons (Neurosurgery), National University Hospital Competition Sponsor: Ministry of Health and…

Catalyst Awardee

Detecting Parkinson’s Disease-Associated Metabolites with Colorimetric Sensor Array and Machine Learning

Koh Tong Wey, M.Sc., Ph.D., and Ian Cheong, LL.B., Ph.D., Temasek Life Sciences Laboratory; and Tan Eng Kind, M.B.B.S., National Neuroscience Institute Competition Sponsor: Ministry of Health and National Research Foundation of Singapore Parkinson’s disease (PD) is a common aging-related debilitating neurological disorder. No drug can reverse disease progression and…

Catalyst Awardee

Enhanced Single Cell Transcriptomics for New Biomarkers and Targets in Cardiovascular Ageing

Roger Foo, M.B.B.S., M.R.C.P., M.D., C.C.S.T., F.R.C.P, and Matthew Ackers-Johnson, Ph.D., M.Phil., M.Sci., National University of Singapore Competition Sponsor: Ministry of Health and National Research Foundation of Singapore Cardiovascular disease (CVD) is the primary cause of morbidity and mortality globally. Related annual US healthcare expenditure exceeds $200bn, of which heart…

Catalyst Awardee

Ergothioneine, the Lesser Known Longevity Nutrient

Irwin Kee Mun Cheah, Ph.D., Feng Lei, D.Phil., and Barry Halliwell, PhD, D.Sc., National University of Singapore Competition Sponsor: Ministry of Health and National Research Foundation of Singapore The naturally occurring thione, ergothioneine, accumulates in the human body at high concentrations primarily from diet. Studies suggest this compound may play…

Catalyst Awardee

Examining Evidence for Transmissible Alzheimer’s Disease

Ajay Sriram Mathuru, Ph.D., and Jan Gruber, M.Sc., Ph.D., National University of Singapore Competition Sponsor: Ministry of Health and National Research Foundation of Singapore Alzheimer’s Disease (AD) is known to develop among many individuals in an age dependent manner. A few genetic variants in enzymes or proteins associated with production…

Catalyst Awardee

Organismal Aging and Oxidants Beyond Macromolecules Damage

Marie-Veronique Clement, M.Sc., Ph.D., and Shazib Pervaiz, M.B.B.S., Ph.D., National University of Singapore Competition Sponsor: Ministry of Health and National Research Foundation of Singapore One prediction of the free radical theory of aging is that oxidative stress shortens organisms’ lifespan because of the damaging effect of oxidants on macromolecules, thereby…


Catalyst Awardee

Personalizing Exercise for Enhancing Healthspan: Using Artificial Intelligence for N-of-1 Exercise Prescription

Goh Jor Ming, M.Sc., Ph.D., Brian Kennedy, Ph.D., and Dean Ho, M.Sc., Ph.D., National University of Singapore Competition Sponsor: Ministry of Health and National Research Foundation of Singapore Exercise exerts physiological effects on multiple organs and tissues and is a powerful “drug” that improves healthspan, depending on the “dose” (frequency,…

Catalyst Awardee

Small RNAs: Big Answers to Healthy Longevity?

Hataitip Tasena, M.Sc., Ph.D., Brian Kennedy, Ph.D., Yvonne Tay, Ph.D., and Maximilian Unfried, M.Sc., National University of Singapore Competition Sponsor: Ministry of Health and National Research Foundation of Singapore Humans have long been searching for the path to longevity. Among the latest but less known possibilities being proposed is PIWI-interacting…

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