National Academy of Medicine Archives - healthylongevitychallenge.org

Democratizing AI-Driven Biological Aging Insights via Routine Medical Imaging and Laboratory Biomarkers

Paul Yi, MD |St. Jude Children’s Research Hospital; Pritam Mukherjee, PhD; Stephanie Dixon, MD, MPH
Competition Sponsor: National Academy of Medicine
Awardee Year: 2025 Accurately assessing biological aging is essential for identifying individuals at risk for accelerated aging, enabling timely intervention. While epigenetic clocks provide an objective measure…

Catalyst Awardee

Reversing Muscle Atrophy and Metabolic Decline with Multi-active Secretomes

Hans Keirstead, PhD | Immunis, Inc.; Gabriel Nistor, MD; Nicole Berchtold, PhD; Scott Greilach, PhD; Thomas Lane, PhD, University of California, Irvine; Mich Drummond, PhD, University of Utah
Competition Sponsor: National Academy of Medicine
Awardee Year: 2025 The current medical approach to manage chronic conditions in aging is to…

Catalyst Awardee

Precision Nutrition for Longevity

Angela M. Zivkovic, PhD | University of California Davis; Joanne K. Agus, PhD; Brian V. Hong, PhD
Competition Sponsor: National Academy of Medicine
Awardee Year: 2025

HDL is more than just “good cholesterol”—it’s a key to long, healthy lives. While early research linked low HDL cholesterol to heart disease,

…

Catalyst Awardee

Design of Mitochondrial Precision Therapeutics Through an AI-guided Synthetic Biology Approach to Enhance Myocyte Resilience and Durability

Mariëlle van Kooten, PhD | Powerhouse Biology, Inc; Rachel Jacobson, PhD
Competition Sponsor: National Academy of Medicine
Awardee Year: 2025

Mitochondrial dysfunction has been causally linked to aging and sarcopenia, yet current therapies fail to target mitochondria directly. Powerhouse Biology is developing AI-driven synthetic mitochondrial therapeutics to enhance cellular resilience

…

Catalyst Awardee

Large Scale Foodborne Pathogen Surveillance System

Digvijay Singh, MSE | Drizzle Health; Bonolo Mathekga, MSE
Competition Sponsor: National Academy of Medicine
Awardee Year: 2025 CDC estimates 48 million people get sick, 128,000 are hospitalized, and 3,000 die from foodborne diseases each year in the United States. Expectedly, it also disproportionately threaten older adults, whose weakened…

Catalyst Awardee

Piloting Social Prescribing for Elderly Patients Experiencing Loneliness

Alan Siegel, MD | Social Prescribing USA; Paul Espinas, MD; Lynn Deguzman; Candyce Kroenke, MPH, ScD
Competition Sponsor: National Academy of Medicine
Awardee Year: 2025

As the U.S. population ages (it is expected to surpass 80 million individuals aged 65 and older by 2040), loneliness among older adults has

…

Catalyst Awardee

Smart Assisted Geriatric Encounters (SAGE): An AI-Powered Home Visit Companion to Assist Aging in Place

Lauren Bangerter, PhD | Health Economics and Aging Research Institute, MedStar Health Research Institute; Georgetown University School of Medicine; Yijung Kim, PhD, Aledade; Karl Eric De Jonge, MedStar Washington Hospital Center; Raj Ratwani, MedStar Health Research Institute; Katie Adams, MS, MedStar Health Research Institute; Allan Fong, MS, MedStar Health Research…

Catalyst Awardee

Digital Care Team for AD Risk Assessment: Integrating Retinal Biomarkers, RWD, and AI-Driven Analysis for Early Detection

Yu Huang, PhD | Indiana University; Jiang Bian, PhD; Xing He, PhD
Competition Sponsor: National Academy of Medicine
Awardee Year: 2025

This project proposes an innovative AI-driven screening tool that combines retinal imaging biomarkers with real-world data to enable early AD risk assessment. The tool can automatically extract retinal information

…

Catalyst Awardee

Breaking the Inflammation-Senescence Cycle: A Targeted Multimodal Approach to Extend Healthspan

Yori Endo, MD, MPhil, BSc | Brigham and Women’s Hospital, Harvard Medical School
Competition Sponsor: National Academy of Medicine
Awardee Year: 2025

As we age, our tissues accumulate senescent cells that secrete inflammatory factors, which in turn induce more senescence in neighboring cells. This self-perpetuating cycle of inflammation and senescence

…

Catalyst Awardee

Design of Wearable, Non-invasive System for Sleep Enhancement

Huiliang Wang, PhD | University of Texas at Austin; Vincent Mysliwiec, UT Health San Antonio; Greg Fonzo
Competition Sponsor: National Academy of Medicine
Awardee Year: 2025

As people age, deep, restorative sleep—called slow-wave sleep—declines significantly. This loss of deep sleep contributes to memory problems, cognitive decline, and increased risk

…

National Academy of Medicine

Sign up for updates