National Academy of Medicine Archives - healthylongevitychallenge.org

Defining drivers of ovarian aging to balance the scales toward healthy longevity

Jennifer Garrison, PhD Competition Sponsor: US National Academy of Medicine The female reproductive system ages precociously – females rapidly lose their reproductive capacity by midlife while somatic tissues continue to function normally. Beyond reproduction, the end of fertility sets off a cascade of negative health effects in women’s bodies that…

Catalyst Awardee

Deciphering mechanisms of disease resistance and longevity in centenarians

George Murphy, PhD, and Thomas Perls, MD, MPH Competition Sponsor: US National Academy of Medicine Rare individuals with exceptional longevity suggest we have within us the potential for longer, more healthful lives. In the last decade, several studies have provided evidence that many centenarians and their offspring delay or escape…

Catalyst Awardee

A new state-wide tele-health model to deliver ADRD tele-assessment and tailored care planning to older adults in low-access, high-risk rural communities

Jenay Beer, PhD; Lisa Renzi-Hammond, PhD; Denise Dizon Everson, Med Competition Sponsor: US National Academy of Medicine People are living longer than ever with Alzheimer’s disease and related dementias (ADRD), but the key to increased longevity and quality of life with ADRD is early and accurate diagnosis. ADRD are underdiagnosed,…

Catalyst Awardee

Delaying menopause and increasing reproductive longevity with Mullerian Inhibiting Substance

David Pepin, PhD; Patricia Donahoe, MD Competition Sponsor: US National Academy of Medicine Fertility clinics around the world measure the levels of a hormone called Mullerian Inhibiting Substance (MIS) as a marker of ovarian “age”. Women are born with a set number of dormant follicles, the “ovarian reserve”, which gradually…

Catalyst Awardee

The Role of Mitochondrial in Stem Cell Transplantation

Atena Zahedi, PhD Competition Sponsor: US National Academy of Medicine Transplantation of human neural stem cells (hNSC) to repair damaged tissues in traumatic injuries has shown promise in pre-clinical studies and early clinical trials. Spinal cord injury (SCI) is marked by a secondary injury phase characterized by an ischemic oxidative…

Catalyst Awardee

Unraveling the Mycobiome: Fungi as a novel class of probiotics to target inflammaging

Eric Schott, PhD, Douglas Kiel, MD, MPH, and Shivani Sahni, PhD Competition Sponsor: US National Academy of Medicine An aging population has led to a significant global increase in age-related diseases including cardiovascular disease, Alzheimer’s, and others. At the core of this is chronic low-grade inflammation known as inflammaging, and…

Catalyst Awardee

Designing music-based interventions for aging-related pain: Sonifying body movement using interactive mobile technology to improve physical and psychological outcomes

Elizabeth Murnane, PhD Competition Sponsor: US National Academy of Medicine Music is potent medicine, positively contributing to human development, disease treatment, and overall well-being throughout the lifespan. Exploring how music-based interventions can transform how we promote healthy aging, this proposal focuses on managing pain, which increases with age and is…

Catalyst Awardee

Repurposing the lightbulb to support healthy ageing

Daniel Joyce, PhD; Michael Webster, PhD Competition Sponsor: US National Academy of Medicine Light is a powerful modifier of human behavior and drives the way that we feel, think, and act. However, in today’s society we don’t get enough light during the day while getting too much light at night,…

Catalyst Awardee

A novel treatment for age-induced loss of muscle strength (frailty)

Stephen Meriney, PhD Competition Sponsor: US National Academy of Medicine More than one third of adults aged 65 and older will fall each year. The Centers for Disease Control report that falls are the leading cause of death relating to injury, and that aged adults are at the greatest risk.…

Catalyst Awardee

A platform for identifying synergistic longevity interventions

George Sutphin, PhD Competition Sponsor: US National Academy of Medicine We are on the precipice of real anti-aging medicine. Over the past several decades, research into the biology of aging has identified nearly a thousand genetic changes and hundreds of drugs capable of extending lifespan in eukaryotic organisms. The discovery…

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