National Academy of Medicine Archives - healthylongevitychallenge.org

Defining drivers of ovarian aging to balance the scales toward healthy longevity

Jennifer Garrison, PhD | Buck Institute for Research on Aging
Competition Sponsor: US National Academy of Medicine
Award year: 2021 The female reproductive system ages precociously – females rapidly lose their reproductive capacity by midlife while somatic tissues continue to function normally. Beyond reproduction, the end of fertility sets off…

Catalyst Awardee

Deciphering mechanisms of disease resistance and longevity in centenarians

George Murphy, PhD, and Thomas Perls, MD, MPH | Boston Medical Center
Competition Sponsor: US National Academy of Medicine
Award year: 2021 Rare individuals with exceptional longevity suggest we have within us the potential for longer, more healthful lives. In the last decade, several studies have provided evidence that many…

Catalyst Awardee

A new state-wide tele-health model to deliver ADRD tele-assessment and tailored care planning to older adults in low-access, high-risk rural communities

Jenay Beer, PhD; Lisa Renzi-Hammond, PhD; Denise Dizon Everson, Med | University of Georgia
Competition Sponsor: US National Academy of Medicine
Award year: 2021 People are living longer than ever with Alzheimer’s disease and related dementias (ADRD), but the key to increased longevity and quality of life with ADRD is…

Catalyst Awardee

Delaying menopause and increasing reproductive longevity with Mullerian Inhibiting Substance

David Pepin, PhD; Patricia Donahoe, MD | Massachusetts General Hospital
Competition Sponsor: US National Academy of Medicine
Award year: 2021 Fertility clinics around the world measure the levels of a hormone called Mullerian Inhibiting Substance (MIS) as a marker of ovarian “age”. Women are born with a set number of…

Catalyst Awardee

The Role of Mitochondrial in Stem Cell Transplantation

Atena Zahedi, PhD | Stem Cell Research Center
Competition Sponsor: US National Academy of Medicine
Award year: 2021 Transplantation of human neural stem cells (hNSC) to repair damaged tissues in traumatic injuries has shown promise in pre-clinical studies and early clinical trials. Spinal cord injury (SCI) is marked by a…

Catalyst Awardee

Unraveling the Mycobiome: Fungi as a novel class of probiotics to target inflammaging

Douglas Kiel, MD, MPH; Shivani Sahni, PhD; and Eric Schott, PhD | Solarea Bio, Inc
Competition Sponsor: US National Academy of Medicine
Award year: 2021 An aging population has led to a significant global increase in age-related diseases including cardiovascular disease, Alzheimer’s, and others. At the core of this is…

Catalyst Awardee

Designing music-based interventions for aging-related pain: Sonifying body movement using interactive mobile technology to improve physical and psychological outcomes

Elizabeth Murnane, PhD | Dartmouth College, School of Engineering
Competition Sponsor: US National Academy of Medicine
Award year: 2021 Music is potent medicine, positively contributing to human development, disease treatment, and overall well-being throughout the lifespan. Exploring how music-based interventions can transform how we promote healthy aging, this proposal focuses…

Catalyst Awardee

A novel treatment for age-induced loss of muscle strength (frailty)

Stephen Meriney, PhD | Department of Neuroscience
Competition Sponsor: US National Academy of Medicine
Award year: 2021 More than one third of adults aged 65 and older will fall each year. The Centers for Disease Control report that falls are the leading cause of death relating to injury, and that…

Catalyst Awardee

A platform for identifying synergistic longevity interventions

George Sutphin, PhD University of Arizona Competition Sponsor: US National Academy of Medicine We are on the precipice of real anti-aging medicine. Over the past several decades, research into the biology of aging has identified nearly a thousand genetic changes and hundreds of drugs capable of extending lifespan in eukaryotic…

Catalyst Awardee

The Aging Exposome: Characterizing Bidirectional Effects of Exposures and Aging

Ram Gouripeddi, MBBS, MS; Julio Facelli, PhD | Department of Biomedical Informatics, University of Utah
Competition Sponsor: US National Academy of Medicine
Award year: 2021 Effects of a lifetime of environmental and lifestyle exposures on aging or age-associated diseases are not well understood. Exposures not only directly affect biological pathways…

National Academy of Medicine

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