National Academy of Medicine Archives - Page 2 of 10

Dawn-to-Dusk Dry Fasting for Rapid Reversal of Aging

Ayse Leyla Mindikoglu, M.D., M.P.H.; Weiwei Dang, PhD; Sung Yun Jung, PhD | Baylor College of Medicine;
Competition Sponsor: US National Academy of Medicine
Awardee Year: 2023 DNA double-strand breaks and DNA methylation pattern changes (epigenetic change) are strongly associated with aging. Our previous studies showed that fasting from…

Catalyst Awardee

Reducing “Inflammaging” for Healthy Aging

Prashant Nagpal, co-Founder, COO; Anushree Chatterjee, Ph.D. co-Founder, CEO | Sachi Bio
Competition Sponsor: US National Academy of Medicine
Awardee Year: 2023 Older age is the leading risk factor for AD, cognitive decline, and a range of cardiometabolic diseases. While different mechanisms can drive these aging-related diseases, a key…

Catalyst Awardee

Leveraging Genetic Determinants of Age-Retained Brown Fat to Identify Novel Therapeutic Targets for Cardiometabolic Disease

Paul Cohen, MD, PhD |The Rockefeller University
Competition Sponsor: US National Academy of Medicine
Awardee Year: 2023 Weight gain is a common feature of human aging and contributes to decreased longevity by contributing to the risk of diabetes, heart disease, and many types of cancer. Humans possess white fat,…

Catalyst Awardee

Restoring mitochondrial function using viral gene reconstitution therapy in aged muscle and heart

Olga Bielska, PhD; Eric Verdin, MD | Buck Institute for Research on Aging
Competition Sponsor: US National Academy of Medicine
Awardee Year: 2023 Mitochondrial dysfunction is a major contributing factor in age-related loss of skeletal muscle mass and cardiovascular disease. Mitochondrial division is a critical process for maintaining mitochondrial function.…

Catalyst Awardee

Cataract screening for elderly nursing home residents using smartphones and artificial intelligence

Nakul Shekhawat, M.D., M.P.H.; Kunal Parikh, PhD; Rama Chellappa, PhD | Johns Hopkins University
Competition Sponsor: US National Academy of Medicine
Awardee Year: 2023
Cataract is a common cause of visual impairment among elderly nursing home residents, who disproportionately suffer from visual impairment due to lack of access to eye…

Catalyst Awardee

Dawn-to-Dusk Dry Fasting for Rapid Reversal of Aging

Ayse Leyla Mindikoglu, M.D., M.P.H.; Weiwei Dang, PhD; Sung Yun Jung, PhD | Baylor College of Medicine
Competition Sponsor: US National Academy of Medicine
Awardee Year: 2023 DNA double-strand breaks and DNA methylation pattern changes (epigenetic change) are strongly associated with aging. Previous studies showed that fasting from dawn…

Catalyst Awardee

A Wearable Ultrasound Sensor for Continuous Blood Pressure Tracking

Sheng Xu, PhD | Softsonics LLC
Competition Sponsor: US National Academy of Medicine
Awardee Year: 2023
Hypertension poses a major challenge in cardiovascular disease prevention and human longevity. The clinical gold standard for evaluating blood pressure is too invasive. Current noninvasive methods for measuring blood pressure only provide…

Catalyst Awardee

Brain stimulation targeting shared networks to improve physical and cognitive functions in older adults

On-Yee Amy Lo, PhD; Brad Manor, PhD | Marcus Institute for Aging Research, Hebrew SeniorLife, and Harvard Medical School; Michael Esterman, PhD | VA Boston Healthcare System; Giulio Ruffini, PhD | Neuroelectrics
Competition Sponsor: US National Academy of Medicine
Awardee Year: 2023 Promotion of physical and cognitive function is…

Catalyst Awardee

Digital Solutions to Reduce Maternal Morbidity and Mortality in Refugee Women

Gunisha Kaur, MD, MA | Weill Cornell Medicine; Stephen Yale-Loehr, JD | Cornell University; Richard Boyer, MD PhD | Weill Cornell Medicine
Competition Sponsor: US National Academy of Medicine
Awardee Year: 2023 Pregnant refugee women have an elevated risk for uncontrolled hypertension, which increases gestational complications including…

Catalyst Awardee

Using Methioninase as a methionine restriction mimetic to delay aging and age-dependent diseases

Andrey Parkhitko, PhD | Aging Institute of UPMC and the University of Pittsburgh
Competition Sponsor: US National Academy of Medicine
Awardee Year: 2023 Aging is a major risk factor for various human pathologies. The incidence of many chronic diseases including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases increases…

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