National Academy of Medicine Archives - Page 2 of 3

The Aging Exposome: Characterizing Bidirectional Effects of Exposures and Aging

Ram Gouripeddi, MBBS, MS; Julio Facelli, PhD Competition Sponsor: US National Academy of Medicine Effects of a lifetime of environmental and lifestyle exposures on aging or age-associated diseases are not well understood. Exposures not only directly affect biological pathways but also have genetic mechanistic influences on disease and well-being. Aging…

Catalyst Awardee

Combating Arterial Aging by Engineering the Gut Virome to Transmit Equol Producing Genes

Justyn Jaworski, PhD and Dan Trott, PhD Competition Sponsor: US National Academy of Medicine Advanced age is the major risk factor for cardiovascular disease (CVD), which is one of the leading causes of death in the industrialized world. Vascular aging manifests itself primarily through increases in large artery stiffness and…

Catalyst Awardee

Transformative oral drugs that reverse muscle weakness and aging in older adults

Stan Watowich, PhD; Harshini Neelakantan, PhD Competition Sponsor: US National Academy of Medicine Every adult over 40 years old faces the relentless loss of skeletal muscle strength, caused primarily by the inability of aging muscles to regenerate fully. In the elderly, decreased muscle strength leads to reduced mobility and physical…

Catalyst Awardee

Dynamic Signature of Cuffless Blood Pressure and Risk of Subclinical Brain Disease and Dementia

Yuan Ma, PhD; Albert Hofman, MD, PhD Competition Sponsor: US National Academy of Medicine Dementia is the most common neurodegenerative disease in older people, associated with high disability and dependency. Hypertension is a key player in the vascular etiology, but the relationship between blood pressure (BP) and dementia is not…

Catalyst Awardee

Advancing Cardiovascular Monitoring: Long-term, Accessible, Multi-Modal Soft Bioelectronics

Nanshu Lu, PhD; Phillip Tan, BS Competition Sponsor: US National Academy of Medicine Cardiovascular disease (CVD) remains the largest cause of death in the world, leading to significant financial and emotional drain. However, current methods of assessing CVD are inadequate: it is impossible to assess the highly variable nature of…

Catalyst Awardee

Identifying Predictive Biomarkers of Effective Immunity in Aging Populations

Wayne Koff, PhD Competition Sponsor: US National Academy of Medicine The world is aging at an unprecedented rate, and we are not prepared. By 2050 nearly 1.6 billion people will be over age 65, creating widespread public health challenges. This aging population will dramatically increase the burden of non-communicable diseases…

Catalyst Awardee

Human Activity Recognition to Avoid Fall Related Injuries in the Older Adult Population

Rebecca Tarbert, DPT, Arun Jayaraman, PT, PhD, and Wamis Singhatat, MSBE Competition Sponsor: US National Academy of Medicine One out of four older adults experience a fall each year and falls are the leading cause of death from injury for older adults in the United States. The cost of falls…

Catalyst Awardee

Community Brain Health in African American Faith-Based Organizations

Dean Sherzai, MD, PhD, Competition Sponsor: US National Academy of Medicine Alzheimer’s disease is the fastest growing epidemic in the United States. Though the disease has affected every family, certain communities are disproportionately affected. The black community and women are at twice the risk of developing the disease. To date…

Catalyst Awardee

Transcranial focused ultrasound for enhanced glymphatic-based delivery of antibodies for brain imaging and therapy

Muna Aryal, PhD, and Tyrone Porter, PhD Competition Sponsor: US National Academy of Medicine We purpose to develop a new strategy for efficient delivery of large-sized agents to a big portion of the brain which is not possible from the existing brain drug delivery technologies. Given that antibodies have the…

Catalyst Awardee

The Role of Sirolimus in Delaying Aging and Age-Related Diseases

Irina Timofte, MD Competition Sponsor: US National Academy of Medicine Recently there is a growing interest in developing effective interventions to slow the aging process and reduce the risk of chronic disease. Drugs that inhibit the mammalian target of rapamycin (mTOR inhibitors) such as sirolimus are promising modulators of the…

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