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Catalyst Awardee

Genetic Regulation of Exceptional Longevity in Rockfishes

Stephen Treaster, PhD | Boston Children’s Hospital and Harvard Medical School
Competition Sponsor: National Academy of Medicine
Awardee Year: 2020 Rockfishes (Sebastes genus), with nearly twenty-fold variation in longevity, are an untapped source of natural experiments in modulating, and resisting, the deleterious effects of age. The longest-lived can maintain health…



Catalyst Awardee

Investigating the Mechanisms of Age Dependent Decline in the Immunosurveillance of Senescent Cells by Natural Killer Cells

Amit Sharma, Ph.D. | SENS Research Foundation; and Judith Campisi, Ph.D. | Buck Institute
Competition Sponsor: National Academy of Medicine
Awardee Year: 2020 Senescent cells are characterized by an irreversible arrest of the cell cycle and secrete a milieu of pro-inflammatory cytokines, chemokines, and growth factors collectively referred to…

Catalyst Awardee

Investigating the Role of Intestinal Alkaline Phosphatase in the Aging-Associated Changes in Gut Barrier and Microbiome Using a Novel Microfluidic Intestine-on-Chip Model

Vidisha Mohad, PhD, Richard Hodin, MD, and Nima Saedi, PhD | Massachusetts General Hospital and Harvard Medical School
Competition Sponsor: U.S. National Academy of Medicine
Awardee Year: 2020 Aging increases the vulnerability to many gastrointestinal diseases and is associated with the chronic inflammation, referred to as inflammaging. Aging- associated alteration…

Catalyst Awardee

Nanocatalysis for the Improvement of Human Healthspan and Lifespan

Karen Ho, PhD | Clene Nanomedicine Inc.
Competition Sponsor: National Academy of Medicine
Awardee Year: 2020 The remarkable property of metal-based nanoparticles to efficiently catalyze chemical reactions has been recognized by the manufacturing industry, where there is growing interest in nanocatalysts as highly active, ‘green alternatives’ that enhance various chemical…


Catalyst Awardee

Resilient Brains: New Insights for Healthy Brain Aging

Michael McConnell, PhD | Lieber Institute for Brain Development; Daniel R. Weinberger, MD |  Lieber Institute for Brain Development and Johns Hopkins University School of Medicine; and Thomas M. Hyde, MD, PhD | Lieber Institute for Brain Development and Johns Hopkins University School of Medicine
Competition Sponsor:…

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