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Japan Agency for Medical Research and Development

Catalyst Awardee

Development of nucleic acid therapeutics with built-in DDS

YOSHIOKA Kotaro, PhD, MD | Tokyo Medical and Dental University;
Competition Sponsor: Japan Agency for Medical Research and Development
Awardee Year: 2023 Nucleic acid therapeutics are rapidly advancing as a new class of molecular-targeting drugs following antibody therapies. However, two main challenges remain: inadequate drug delivery to target tissues and…

Catalyst Awardee

Development of prognosis prediction model and disease-modifying therapy by integrating multilevel bioinfomatics and MRI

HATTORI Nobutaka, MD, PhD | Juntendo University School of Medicine; SAIKI Shinji, MD, PhD; SAKO Wataru, MD, PhD
Competition Sponsor: Japan Agency for Medical Research and Development
Awardee Year: 2023 With the aging of society, the number of patients with neurodegenerative diseases, especially Parkinson’s disease (PD), for which aging…

Catalyst Awardee

Elucidation of reprogramming mechanism of senescent cells to establish advanced technology for extending healthy life expectancy

  JOHMURA Yoshikazu, PhD | Division of Cancer and Senescence Biology, Cancer Research Institute, Kanazawa University
Competition Sponsor: Japan Agency for Medical Research and Development
Awardee Year: 2022 The accumulation of senescent cells plays a crucial role in aging and age-related diseases. Indeed, removal of senescent cells, “Senolysis”, can ameliorate…

Catalyst Awardee

Novel development of pain evaluation devices and nerve regeneration tools using nerve organoids derived from human iPS cells

  SHIBATA Shinsuke, MD, PhD  | Niigata University, Graduate School of Medical and Dental Sciences, Division of Microscopic Anatomy;  HAYATSU Manabu; KIMURA Hiroo; KAWADA Jiro; OKUYAMA Kentaro
Competition Sponsor: Japan Agency for Medical Research and Development
Awardee Year: 2022 To achieve healthy longevity in the aging society that the world…


Catalyst Awardee

The Correlation of ectopic calcification signatures in the ageing eye and cardiovascular system

Maekawa Tomoki, PhD, DDS; Tan Cheng Sim, Anna, MBBS;  Pena-Silva, Ricardo A. PhD Competition Sponsor: Japan Agency for Medical Research and Development Ageing has contradictory effects on calcium metabolism, causing bone demineralization (osteoporosis) while in blood vessels and soft tissues proinflammatory cytokines activate osteogenesis and biomineralization, resulting in ectopic calcification.…





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