Japan Agency for Medical Research and Development Archives

The Correlation of ectopic calcification signatures in the ageing eye and cardiovascular system

Maekawa Tomoki, PhD, DDS; Anna Tan Cheng Sim, MBBS; Ricardo A. Pena-Silva, PhD Competition Sponsor: Japan Agency for Medical Research and Development Ageing has contradictory effects on calcium metabolism, causing bone demineralization (osteoporosis) while in blood vessels and soft tissues proinflammatory cytokines activate osteogenesis and biomineralization, resulting in ectopic calcification.…

Catalyst Awardee

Rewiring inter-organ immuno-metabolic crosstalks in the ageing bone marrow

Nakamura-Ishizu Ayako, PhD, MD; Weiqiang Chen, PhD, MS; Celia Martinez-Jimenez, MS, PhD Competition Sponsor: Japan Agency for Medical Research and Development Ageing is characterised by the progressive decline of physiological and cellular functions. However, little is known about how our different tissues respond to aging and whether every cell in…

Catalyst Awardee

Age-dependent trajectory of exosomal protein distribution in healthy aging and Alzheimerʼs disease

Hoshino Ayuko, PhD, MS; Lav Varshney, PhD; Alexandru Hanganu, PhD Competition Sponsor: Japan Agency for Medical Research and Development Exosomes are small packages of proteins and genetic material that are released into the blood from various cell types and organ systems. They then flow through the blood and into other…

Catalyst Awardee

Development of in-body tissue-engineered autologous vascular grafts (Biotube)

Miyamoto Shinji, PhD; Nakayama Yasuhide, PhD; Yambe Tomoyuki, PhD; Tajikawa Tsutomu, PhD; Iwai Ryosuke, PhD; Takeshi Terazawa, PhD Competition Sponsor: Japan Agency for Medical Research and Development It’s most reassuring if you can use your own tissues for implantation treatment. However, the amount and type of your own tissues available…

Catalyst Awardee

No autograft: Bone regeneration using carbonate apatite bone replacement

Nakashima Yasuharu, PhD; Ishikawa Kunio, PhD Competition Sponsor: Japan Agency for Medical Research and Development Carbonate apatite honeycomb (CO3Ap HC) arterial bone is the first 100% chemically pure artificial bone made from bone mineral, i.e., carbonate apatite. CO3Ap artificial bone is replaced by actual bone with time based on so-called…

Catalyst Awardee

Compounds that suppress the aging process through selective autophagy

Arimoto Hirokazu, PhD Competition Sponsor: Japan Agency for Medical Research and Development Autophagy is a major degradation system in cells. Best known is its ability to degrade existing proteins into amino acids during starvation. Autophagy also plays a vital role in the protection of the human body by removing invading…

Catalyst Awardee

Elucidation of the mechanism of autophagy driven by liquid-liquid phase separation

Fujioka Yuko, PhD Competition Sponsor: Japan Agency for Medical Research and Development Life science has entered a new phase to reconsider various phenomena, including autophagy, after discovery of liquid-liquid phase separation in cells. Autophagy is a major intracellular proteolysis pathway and plays an important role in proteostasis, which is essential…

Catalyst Awardee

The mechanisms of lifespan regulation by dietary manipulation

Obata Fumiaki, PhD Competition Sponsor: Japan Agency for Medical Research and Development Almost all animals, including humans, develop into adults and eventually age over time. As an environmental factor, dietary intake is essential throughout life. Diet contributes to metabolic and physiological homeostasis via nutrition, the composition of which is modulated…

Catalyst Awardee

The mechanism for the functional decline of aged neurons by comprehensive analysis of chromatin structure

Kishi Yusuke, PhD Competition Sponsor: Japan Agency for Medical Research and Development Prevention or restoration of the decline in memory associated with aging is one of the most important issues for healthy aging. In the brain, which controls memory, neurons are responsible for processing information, and the function, or potential,…

Catalyst Awardee

Clarifying the origins and very early processes of aging in tissue

Susaki Etsuo A., PhD Competition Sponsor: Japan Agency for Medical Research and Development Clarifying the origin and progression mechanism of aging inside tissue is the most fundamental and vital question in aging research. However, the rareness of such very early aging foci has prevented the identification and investigation of mechanisms…

Japan Agency for Medical Research and Development

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