Japan Agency for Medical Research and Development Archives - Page 2 of 6

A better prediction of onset-risk and onset-age using personal genomes

Morishita Shinichi, PhD Competition Sponsor: Japan Agency for Medical Research and Development The risk of getting a disease and the age of onset vary from person to person. If we can predict the risk and age of onset of disease for each individual, we can take preventive measures in advance…

Catalyst Awardee

Patch-type muscle sensing device for early detection of Frailty

Takei Yusuke, PhD Competition Sponsor: Japan Agency for Medical Research and Development We propose a patch-type sensor for early detection of frailty, which evaluates muscle quality (muscle mass, muscle strength, muscle fatigue, muscle contraction speed) from a mechanomyogram generated when muscles are contracted by electrical stimulation. This sensor is expected…

Catalyst Awardee

The mechanism of developing dementia through age-related metabolic change

Tonoki Ayako, PhD Competition Sponsor: Japan Agency for Medical Research and Development In a super-aging society, an increase in dementia patients is one of the social problems to be solved. Dysregulation of insulin signal associated with diabetes and obesity is known as one of the causes of increasing the risk…

Catalyst Awardee

Development of High Throughput 3D-Patient Cancer Culture System with Anticancer Drug Exposure Through Blood Capillary

Matsusaki Michiya, PhD; Katayama Ryohei, PhD Competition Sponsor: Japan Agency for Medical Research and Development “ancer is still unsolved severe disease because of the inter- and intra-tumor genetic heterogeneity. Thus, personalized cancer medicine has been strongly desired to find the best therapeutic strategy for each patient. To achieve it, in…

Catalyst Awardee

Age-related Physiological Dysfunction Based on Clock Aging

Hikari Yohitane, Ph.D., The University of Tokyo
Competition Sponsor: Japan Agency for Medical Research and Development The circadian clock generates transcriptional rhythms with a cycle of about 24 hours, and makes genes function only at the required time. Therefore, deficiency of the clock gene causes not only sleep disorders but…

Catalyst Awardee

Artificial Intelligence-based Diagnosis and Treatment of Age-related Neuropsychiatric Disorders

Mitsuo Kawato, Ph.D., Advanced Telecommunications Research Institute International, Brain Information Communication Research Laboratory Group; Tomokazu Motegi, M.D., Ph.D.; Advanced Telecommunications Research Computational Neuroscience Laboratories; Jessica E. Taylor, Ph.D.,
Advanced Telecommunications Research Computational Neuroscience Laboratories
Competition Sponsor: Japan Agency for Medical Research and Development We have previously identified brain activity patterns…

Catalyst Awardee

Basic Research for Creation of Exercise Pills that Improve QOL of the Elderly by Combatting Sarcopenia and Frailty

Toshihiko Ogura, Ph.D., M.D., Tohoku University; Toshio Hakoshima, Ph.D., Nara Institute of Science and Technology
Competition Sponsor: Japan Agency for Medical Research and Development Medical intervention that keeps elderly people socially, economically and physically active would have great beneficial impacts on our society aging rapidly all over the world. To…

Catalyst Awardee

Cholinergic Input in Fast Versus Slow Cognitive Decline Upon Aging

Yusuke Tsuno, Ph.D., Kanazawa University; Ulkuhan Guler, Ph.D., Worcester Polytechnic Institute; Luisa Lopes, Ph.D., Instituto de Medicina Molecular João Lobo Antunes
Competition Sponsor: Japan Agency for Medical Research and Development As people age, some maintain the cognitive function, while others suffer from rapid cognitive decline. It is thought that the…

Catalyst Awardee

Development of Diagnosis and Therapeutics for Age-related Diseases Through the Research of D-amino Acids

Tomonori Kimura, Ph.D., M.D., National Institutes of Biomedical Innovation
Competition Sponsor: Japan Agency for Medical Research and Development Most amino acids have D- and L-enantiomers (chiral bodies). Although D-amino acids are present only in trace amounts unlike abundant L-amino acids, we have demonstrated that trace amounts of D-amino acids are…

Catalyst Awardee

Development of High-precision Diagnostics and Treatment Evaluation Technique of Neurological Disorder using Quantitative fMRI Harmonization Technique

Daisuke Kokuryo, Ph.D., Kobe University; Takashi Itahashi, Ph.D., Showa University; Chika Sato, Ph.D., National Institutes for Quantum and Radiological Science and Technology; Shigeyoshi Saito, Ph.D., Osaka University
Competition Sponsor: Japan Agency for Medical Research and Development The proposed high-precision diagnostic and treatment evaluation technique aims to provide a quantitative evaluation…

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