National Academy of Medicine Archives - healthylongevitychallenge.org

Enabling early glaucoma detection and monitoring through a low-cost, portable, non-corneal IOP measurement device for any setting

Joshua de Souza, MSE; Digvijay Singh, MSE |Drizzle Health
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 In our endeavor to combat glaucoma—the leading cause of irreversible blindness—we propose a pioneering device. This compact, affordable, portable, and modular tool is crafted to effortlessly complement existing ocular instruments, aiming…

Catalyst Awardee

Smart Kneepads for Aging Monitoring and Therapy

Shiqi Guo, PhD | Massac National Academy of Medicine husetts General Hospital Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Our initiative aims to advance health equity for older adults through the introduction of innovative ‘smart’ kneepads integrating micro-scale sensors and stimulators. These cutting-edge platforms are meticulously designed to…

Catalyst Awardee

Using Naked Mole-Rat Lymph Nodes as Bioreactor for Ovarian Rejuvenation

Miguel Angel Brieño-Enríquez, MD, PhD | Magee-Womens Research Institute, Department of OBGYN and Reproductive Sciences, University of Pittsburgh
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 In humans, the ovary ceases its functions little more that the halfway through a woman’s lifespan, leading to a very long post reproductive…

Catalyst Awardee

PranaSense: A Desktop Solution in Breath-Based Biomarker Detection for Alzheimer’s Disease Diagnostics

Marshall Ligare, PhD | Outlier Technology, LLC; John Cowart Jr., PhD; Peter Gray, PhD; Brian Stahl, PhD; Will Pro, PhD
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Recent insights into the pathogenesis of Alzheimer’s Disease (AD) have shown that the relative ratios of several metabolic byproducts in…

Catalyst Awardee

Deep Learning to Estimate Aging from Magnetic Resonance Imaging (MRI)

Matthias Jung, MD | Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital; Vineet K. Raghu, PhD; Jakob Weiss, MD
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Cardiovascular disease (CVD) is the leading cause of death in the United States. Current cardiovascular guidelines and treatments rely…

Catalyst Awardee

Identifying Language Biomarkers to Flag Prodromal Cognitive Decline in At Risk and Underserved Aging Populations

Brielle C. Stark, PhD | Indiana University Bloomington; Sharlene Newman, PhD; Yanyu Xiong, PhD
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Identifying aging individuals in cognitive decline’s prodromal stages is critical for implementing effective intervention to prevent or slow decline. However, prodromal changes currently cannot be reliably identified…

Catalyst Awardee

A Humanized CHIP Model for Studying the Origins of Age-Related Chronic Inflammatory Diseases

Isak W. Tengesdal, PhD | Department of Pathology, Stanford Medicine
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Age-related chronic inflammatory diseases represent a major incoming burden as the proportion of the world’s population over 60 years is expected to jump to 22% by 2050 according to the World…

Catalyst Awardee

Enhancing Sleep in Older Adults Using Auditory Stimulation: A Machine Learning Approach

Stephanie Buss, MD | Beth Israel Deaconess Medical Center, Harvard Medical School; Brandon Westover, MD, PhD; Wolfgang Ganglberger, PhD; Mouhsin Shafi, MD, PhD; Lorella Battelli, PhD
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Older adults face a risk of cognitive decline which increases with each decade of life,…

Catalyst Awardee

System for Improving Quality of Life and Mobility in Kidney and Liver Failure

Dayong Gao, PhD | University of Washington; Suhail Ahmad, MD; Alexander Novokhodko, MS
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Advanced Multi-Organ Replacement (AMOR) is a life support system that removes protein bound toxins and excess fluid from patient blood. It has been validated in a pilot…

Catalyst Awardee

Antisense Oligonucleotide (ASO)-Based Approach for Enhancing Healthspan and Lifespan

Andrew Nguyen, PhD | Saint Louis University; Susan Farr, PhD
Competition Sponsor:National Academy of Medicine
Awardee Year: 2024

Aging is a major risk factor for many chronic diseases as well as geriatric syndromes, and therapeutics that delay or slow the progression of aging remain elusive. There is great potential to

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