National Academy of Medicine Archives - Page 4 of 5

Care Corps USA: A National Service Model Addressing the Aging Sector Workforce

Nihal Satyadev, MPH, University of Medicine and Health Sciences; Norma Bostarr, and Heena Doshi, MPH
Competition Sponsor: National Academy of Medicine In the United States, more than 10,000 people turn 65 every day. Put this statistic alongside the fact that our birth rate is at an all-time low, and you…

Catalyst Awardee

Centenarian Species Genomes Project

Glenn Gerhard, MD, Lewiz Katz School of Medicine at Temple University; and Sudhir Kumar, PhD, Institute for Genomics and Evolutionary Medicine, Temple University
Competition Sponsor: National Academy of Medicine The central tenet to our idea is that in order to extend the human healthspan, the biological mechanisms that specify maximum…

Catalyst Awardee

Deep Learning to Predict Biological Age and Longevity from Chest Radiographs

Vineet Raghu, PhD, Massachusetts General Hospital; Jakob Weiss, MD, Dana-Farber Cancer Institute; and Michael Lu, MD, MPH, Massachusetts General Hospital Competition Sponsor: U.S. National Academy of Medicine Age-related chronic disease causes 60% of deaths in the US. Primary prevention (e.g. statin to prevent cardiovascular disease) and screening (e.g. screening for…

Catalyst Awardee

Development of an Implantable, Continuously Operating, Patient-Friendly Renal Replacement System for Transforming Home Dialysis

Nikhil Shah, DO, MPH, Nephrodite, Inc., University of Texas, Austin; and Hiep T. Nguyen, MD, Banner Health System
Competition Sponsor: National Academy of Medicine We are developing a fully implantable, fully mechanical, continuous hemodialysis device that is designed to be a bridge to transplant for eligible patients and/or a destination…

Catalyst Awardee

Elucidating Mechanisms Through Which the Gut Microbiome Can Be Optimized Across the Human Lifespan

Nathan D. Price, PhD, Institute for Systems Biology; Sean Gibbons, PhD, Institute for Systems Biology; Leroy Hood, MD, PhD, Institute for Systems Biology and Providence St. Joseph Health; and Eric Orwoll, MD, Oregon Health Sciences University Competition Sponsor: U.S. National Academy of Medicine The gut microbiome has important effects on…

Catalyst Awardee

Genetic Regulation of Exceptional Longevity in Rockfishes

Stephen Treaster, PhD, Boston Children’s Hospital and Harvard Medical School
Competition Sponsor: National Academy of Medicine Rockfishes (Sebastes genus), with nearly twenty-fold variation in longevity, are an untapped source of natural experiments in modulating, and resisting, the deleterious effects of age. The longest-lived can maintain health and function for over…

Catalyst Awardee

Halting Inflammaging Through Skin Barrier Restoration

Katrina Abuabara, MD, MA, MSCE, University of California, San Francisco (UCSF), and University of California, Berkeley; Timothy Berger, MD, UCSF; Steven Cummings, MD, San Francisco Coordinating Center and UCSF; Theodora Mauro, MD, UCSF and Veterans Administration Health Care System; and Charles E. McCulloch, PhD, UCSF Competition Sponsor: U.S. National Academy…

Catalyst Awardee

Improving Health for the Aging through Daily Vital Signs Monitoring

David Borkholder, PhD, Adam Smith, MFA, Linwei Wang, PhD, and Caroline Easton, PhD, Rochester Institute of Technology
Competition Sponsor: National Academy of Medicine Vital signs are objective measures of physiological function that are used to monitor acute and chronic diseases, providing critical data on an individual’s health status. Monitoring daily…

Catalyst Awardee

Investigating the Mechanisms of Age Dependent Decline in the Immunosurveillance of Senescent Cells by Natural Killer Cells

Amit Sharma, Ph.D., SENS Research Foundation; and Judith Campisi, Ph.D., Buck Institute
Competition Sponsor: National Academy of Medicine Senescent cells are characterized by an irreversible arrest of the cell cycle and secrete a milieu of pro-inflammatory cytokines, chemokines, and growth factors collectively referred to as the Senescence-Associated Secretory Phenotype (SASP)…

Catalyst Awardee

Investigating the Role of Intestinal Alkaline Phosphatase in the Aging-Associated Changes in Gut Barrier and Microbiome Using a Novel Microfluidic Intestine-on-Chip Model

Vidisha Mohad, PhD, Richard Hodin, MD, and Nima Saedi, PhD, Massachusetts General Hospital and Harvard Medical School Competition Sponsor: U.S. National Academy of Medicine Aging increases the vulnerability to many gastrointestinal diseases and is associated with the chronic inflammation, referred to as inflammaging. Aging- associated alteration in the microbiota has…

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