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Catalyst Awardee

Centenarian Species Genomes Project

Glenn Gerhard, MD, Lewiz Katz School of Medicine at Temple University; and Sudhir Kumar, PhD, Institute for Genomics and Evolutionary Medicine, Temple University
Competition Sponsor: National Academy of Medicine The central tenet to our idea is that in order to extend the human healthspan, the biological mechanisms that specify maximum…

Catalyst Awardee

Genetic Regulation of Exceptional Longevity in Rockfishes

Stephen Treaster, PhD, Boston Children’s Hospital and Harvard Medical School
Competition Sponsor: National Academy of Medicine Rockfishes (Sebastes genus), with nearly twenty-fold variation in longevity, are an untapped source of natural experiments in modulating, and resisting, the deleterious effects of age. The longest-lived can maintain health and function for over…

Catalyst Awardee

Halting Inflammaging Through Skin Barrier Restoration

Katrina Abuabara, MD, MA, MSCE, University of California, San Francisco (UCSF), and University of California, Berkeley; Timothy Berger, MD, UCSF; Steven Cummings, MD, San Francisco Coordinating Center and UCSF; Theodora Mauro, MD, UCSF and Veterans Administration Health Care System; and Charles E. McCulloch, PhD, UCSF Competition Sponsor: U.S. National Academy…

Catalyst Awardee

Investigating the Mechanisms of Age Dependent Decline in the Immunosurveillance of Senescent Cells by Natural Killer Cells

Amit Sharma, Ph.D., SENS Research Foundation; and Judith Campisi, Ph.D., Buck Institute
Competition Sponsor: National Academy of Medicine Senescent cells are characterized by an irreversible arrest of the cell cycle and secrete a milieu of pro-inflammatory cytokines, chemokines, and growth factors collectively referred to as the Senescence-Associated Secretory Phenotype (SASP)…

Catalyst Awardee

Investigating the Role of Intestinal Alkaline Phosphatase in the Aging-Associated Changes in Gut Barrier and Microbiome Using a Novel Microfluidic Intestine-on-Chip Model

Vidisha Mohad, PhD, Richard Hodin, MD, and Nima Saedi, PhD, Massachusetts General Hospital and Harvard Medical School Competition Sponsor: U.S. National Academy of Medicine Aging increases the vulnerability to many gastrointestinal diseases and is associated with the chronic inflammation, referred to as inflammaging. Aging- associated alteration in the microbiota has…

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