National Academy of Medicine Archives - healthylongevitychallenge.org

Microgravity as a model for studying sarcopenia and drug screening

Ngan F. Huang, PhD | Associate Professor of Cardiothoracic Surgery, Stanford University; Thomas Rando, MD, PhD | Director of the UCLA Broad Stem Cell Research Center; Philip S Tsao, PhD | Professor of Cardiovascular Medicine, Stanford University
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 With aging,…

Catalyst Awardee

The Neurobiological Mechanisms of Social Connection in Aging Adults

Debra S. Karhson, PhD | University of New Orleans; Mya Scott; Charlie Weinstein; Kate Yurgil, PhD
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Social connection is an essential facet of human life that when impaired can radically lower the quality of life. Feelings of social disconnection increase…

Catalyst Awardee

Positive Childhood Experiences to Counteract Childhood Adversity for Healthy Longevity in Marginalized Communities

Angela Narayan, PhD | University of Denver
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 For the past 25 years, the fields of medicine, psychology, and public health have emphasized the effects of adverse childhood experiences (ACEs) on adulthood health problems, poorer longevity, and earlier mortality. The ACE literature…

Catalyst Awardee

Enabling early glaucoma detection and monitoring through a low-cost, portable, non-corneal IOP measurement device for any setting

Joshua de Souza, MSE; Digvijay Singh, MSE |Drizzle Health
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 In our endeavor to combat glaucoma—the leading cause of irreversible blindness—we propose a pioneering device. This compact, affordable, portable, and modular tool is crafted to effortlessly complement existing ocular instruments, aiming…

Catalyst Awardee

Smart Kneepads for Aging Monitoring and Therapy

Shiqi Guo, PhD | Massachusetts General Hospital Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Our initiative aims to advance health equity for older adults through the introduction of innovative ‘smart’ kneepads integrating micro-scale sensors and stimulators. These cutting-edge platforms are meticulously designed to seamlessly integrate into daily…

Catalyst Awardee

Using Naked Mole-Rat Lymph Nodes as Bioreactor for Ovarian Rejuvenation

Miguel Angel Brieño-Enríquez, MD, PhD | Magee-Womens Research Institute, Department of OBGYN and Reproductive Sciences
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 In humans, the ovary ceases its functions little more that the halfway through a woman’s lifespan, leading to a very long post reproductive period. We recently…

Catalyst Awardee

PranaSense: A Desktop Solution in Breath-Based Biomarker Detection for Alzheimer’s Disease Diagnostics

Marshall Ligare, PhD | Outlier Technology, LLC; John Cowart Jr., PhD; Peter Gray, PhD; Brian Stahl, PhD; Will Pro, PhD
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Recent insights into the pathogenesis of Alzheimer’s Disease (AD) have shown that the relative ratios of several metabolic byproducts in…

Catalyst Awardee

Deep Learning to Estimate Aging from Magnetic Resonance Imaging (MRI)

Matthias Jung, MD | Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital; Vineet K. Raghu, PhD; Jakob Weiss, MD
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Cardiovascular disease (CVD) is the leading cause of death in the United States. Current cardiovascular guidelines and treatments rely…

Catalyst Awardee

Identifying Language Biomarkers to Flag Prodromal Cognitive Decline in At Risk and Underserved Aging Populations

Brielle C. Stark, PhD | Indiana University Bloomington; Sharlene Newman, PhD; Yanyu Xiong, PhD
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Identifying aging individuals in cognitive decline’s prodromal stages is critical for implementing effective intervention to prevent or slow decline. However, prodromal changes currently cannot be reliably identified…

Catalyst Awardee

A Humanized CHIP Model for Studying the Origins of Age-Related Chronic Inflammatory Diseases

Isak W. Tengesdal, PhD | Department of Pathology, Stanford Medicine
Competition Sponsor: National Academy of Medicine
Awardee Year: 2024 Age-related chronic inflammatory diseases represent a major incoming burden as the proportion of the world’s population over 60 years is expected to jump to 22% by 2050 according to the World…

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