Catalyst Awardee

Project Description

A High-sensitive Lung Cancer Screening Breath Analysis System Based on Separation-Sensing

Meixiu Sun, PhD | Institute of Biomedical Engineering ,Chinese Academy of Medical Sciences; Weigui Fu,PhD;Jichun Yang,PhD
Competition Sponsor:
 Chinese Academy of Medical Sciences
Awardee Year: 2023

Effective screening methods have the potential to enhance the survival rate among individuals diagnosed with lung cancer. Notably, breath analysis offers several advantages, including its non-invasive nature, real-time results, and simplicity. Currently, research on breath markers for lung cancer is progressing rapidly towards clinical implementation. Nevertheless, the existing mass spectrometry technology is both expensive and cumbersome, necessitating approximately 10 hours of vacuum preparation and specialized expertise for operation. In contrast, cavity ringdown spectroscopy (CRDS) presents a portable, cost-effective, and user-friendly alternative. However, the detection accuracy of hypertrace lung cancer marker gas is hindered by the interference of non-detection gas spectral interference. To address this issue, it is suggested to enhance the selectivity of CRDS technology by integrating it with gas separation membrane technology. This integration aims to develop a lung cancer screening breath analysis system that is characterized by high precision, stability, and integration. This objective will be achieved through the implementation of six module solutions and an integrated control design.

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