Chan Wu, MD | Chinese Academy of Medical Sciences; Rongping Dai, MD; Zhikun Yang, MD; Huan Chen, MD; Mingyue Luo, MD; Meng Wang, MD
Competition Sponsor: Chinese Academy of Medical Sciences
Awardee Year: 2025
High myopia is a major public issue in global visual health, and posterior scleral dilation is the main pathological mechanism of high myopia fundus lesions. Existing posterior scleral contraction or reinforcement materials have limitations in long-term safety and efficacy stability. Therefore, it is urgent to develop new materials for posterior scleral retraction surgery and explore related mechanisms of action. This study is based on electrospun polyurethane membrane, and significantly improves its mechanical properties (such as tensile strength and elastic modulus) and biocompatibility by optimizing the process parameters and
component ratios of the membrane material. At the same time, the safety and effectiveness of the membrane material were verified through animal experiments, and the effects of the membrane material on the proliferation, migration, and anti-inflammatory properties of scleral fibroblasts were investigated. The biological mechanism of the material promoting extracellular matrix (ECM) remodeling in sclera was systematically analyzed. This study constructed a complete system of “material design performance optimization biological regulation mechanism analysis”, confirming the advantages of electrospun polyurethane membrane in mechanical matching, biocompatibility, and ECM regulation, and opening up a new path for the treatment of complications of high myopia.