Catalyst Awardee

Project Description

A Novel in situ Coronary Photo-cross linking Natural Vascular Scaffold (NVS) System

Chen Han, PhD | Zhongshan Hospital; Ge Junbo, PhD; Shen Li, PhD;
Competition Sponsor:
 Chinese Academy of Medical Sciences
Awardee Year: 2023

 

Coronary artery disease (CAD) is a major cause of global disease-related deaths, posing significant challenges to public health. Although drug-eluting stents have reduced restenosis rates, long-term use can lead to neointimal hyperplasia and restricted blood vessel movement. In response, the “Leave Nothing Behind” approach has emerged as a new direction in coronary intervention. However, current options like biodegradable stents and drug-coated balloons have limitations.
To address these shortcomings, we propose inducing collagen fiber cross-linking after vascular dilation to create an in-situ natural vascular scaffold (NVS). The irregular mesh-like arrangement of collagen fibers within the extracellular matrix allows the NVS to slow down drug release and maximize the effectiveness of anti-proliferative drugs, avoiding immediate stenosis while promoting vascular repair.
Our preliminary research involved the development of lysine-arginine dendrimeric photosensitive intelligent materials (NIPD) that mimic collagen fibers. We verified their safety and cross-linking effectiveness on vascular tissues. Through an NIPD-coated NVS system with an embedded optical fiber, we demonstrated feasibility in small pig peripheral blood vessels.
Next, we plan to validate the feasibility and effectiveness of NIPD-NVS in large animal models of coronary artery injury while conducting mechanistic studies. Additionally, we aim to optimize the NVS system by incorporating paclitaxel drug coatings, providing robust support and repair capabilities to damaged blood vessels.
By addressing the technical limitations of existing interventions, our project aims to achieve natural vascular repair without the need for permanent implants. This research has the potential to revolutionize the prevention and treatment of common cardiovascular diseases.

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