Catalyst Awardee

Project Description

A prospective cohort study of OLIF/MIS-TLIF-based Mini-invasive treatment modality for Degenerative Lumbar Scoliosis(OTM-DLS)

Wu Hao, MD; Wang Kai, MD; Cheng Lei, MD

Competition Sponsor: Chinese Academy of Medical Sciences

Reduction of daily life activity is one of the main factors that contribute to short life span in old-aged population. Degenerative lumbar disease, in particular, degenerative scoliosis which mainly occurred in old-aged population with a mean age at presentation of 60 years and an approximate prevalence of 6% in adults older than 50 years old and 15% in older than 60 years old, could cause low back & lower limb pain and reduce physical activity in daily life. Traditional treatment modality for degenerative scoliosis was transforaminal lumbar interbody fusion (TLIF), but this treatment could cause large surgical injury, consequently, traditional TLIF is not optimal treatment strategy for old-aged patients, instead, mini-invasive treatment modality should be pursued for old-aged patients. Both mini-invasive oblique lumbar interbody fusion (OLIF) and mini-invasive surgery TLIF (MIS-TLIF) are mini-invasive surgery for degenerative lumbar disease. However, the role of OLIF and MIS-TLIF in degenerative lumbar scoliosis is underdetermined. In the present study, we aim to investigate the feasibility of OLIF/MIS-TLIF-based treatment modality for degenerative lumbar scoliosis. This is a prospectively designed cohort study whereby a comparison of safety and efficacy between OLIF/MIS-TLIF-based treatment modality and traditional TLIF will be made. The objective of the study is to evaluate the feasibility of OLIF/MIS-TLIF-based treatment modality for degenerative lumbar scoliosis and establish the technical criteria of OLIF/MIS-TLIF-based treatment modality for degenerative lumbar scoliosis. Prior to initiation of this study, our previous work revealed that patients with degenerative lumbar disease who received OLIF or MIS-TLIF therapy achieved favorable outcome, this encourages us to investigate the role of OLIF/MIS-TLIF-based treatment modality for degenerative lumbar scoliosis; and, our team is the first neurospine team that perform OLIF and MIS-TLIF.

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