Catalyst Awardee

Project Description

Analysis of tumor molecular profile in older patients and its clinical application in diagnosis and treatment

Wenbin Li, PhD | National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College; Yan Li,PhD; Yi Zhang,PhD; Xuemin Xue,PhD;
Lin Li,PhD
Competition Sponsor:
 Chinese Academy of Medical Sciences
Awardee Year: 2023

Older adults are a high-risk population for malignant tumors, often accompanied by organ function decline and various comorbidities. They have a shorter survival period and poorer prognosis. There are differences between older and younger patients in terms of the distribution of tumor histological subtypes and molecular variations. The identification of potential beneficiaries among older patients for targeted therapy, evaluation of treatment risks and expected outcomes, and the development of precise individualized treatment plans are urgent tasks in dealing with elderly cancer patients. In this study, cancer patients were collected from the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, between 2013 and 2023, and advanced techniques such as multiplex immunofluorescence and next-generation sequencing were used to analyze the genomic mutation spectrum characteristics of elderly solid tumor patients. A molecular subtype with prognostic significance was constructed by combining patient clinical prognostic information, aiming to explore the similarities and differences between the elderly population in China and younger patients in terms of pathological characteristics, molecular phenotypes, and prognostic factors in common tumors (lung cancer, breast cancer, and colorectal cancer). This research aims to assist clinicians in providing more rational personalized treatment plans and improving the prognosis of elderly cancer patients.

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