Catalyst Awardee

Project Description

Critical pathways and optimal strategies for healthy ageing and longevity among the Chinese population

Xiaoming Shi, PhD; Chen Mao, PhD; Juan Zhang, PhD; Yue Zhang, PhD; Yuebin Lv, PhD; Zhihao Li, PhD; Wanying Shi, PhD candidate; Jinhui Zhou, PhD candidate; Xiru Zhang, PhD candidate; Luojia Deng, PhD candidate; Yuan Wei, PhD candidate; Bing Wu, PhD candidate

Competition Sponsor: Chinese Academy of Medical Sciences

Findings from studies in China and other countries have suggested that healthy longevity are closely associated with multiple factors such as genetics, environment, lifestyle, social behavior, and mental health. However, existing evidence is limited to select key factors and comprehensive effects, and draw conclusions about the cause-effect association. This study is to build on existing work led by our team like Chinese Longitudinal Healthy Longevity Survey from 1998 to 2018, and Healthy Ageing and Biomarkers Cohort from 2008 to 2021. Using the obtained data, we will explore the underlying factors, in particular causes of healthy ageing and longevity, conduct Mendelian randomization and difference-in-difference analysis to test causal associations, find the weakest links in the etiological chains, identify the most important and modifiable factors and their interactions in the web of causation, and clarify the critical pathways of healthy ageing and longevity. Evidence-based medical research will be carried out to verify relationships and the magnitudes of effects of multi-dimensional factors of environmental, genetic, biological factors on healthy ageing and longevity, then to look at the optimal strategies; Delphi method will be conducted to reach consensus on critical pathways and optimal strategies. Stakeholder mapping will be conducted to identify key stakeholders, and analyze the contexts to implement the critical pathways and optimal strategies for healthy ageing and longevity among the Chinese population. The findings will provide essential evidences for the government to respond to ageing society and provide support for scientific decision-making on promoting healthy ageing and longevity of Chinese.

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