Lizhou Dou, MD | Cancer Hospital, Chinese Academy of Medical Sciences; Jiangtao Chu, MD；Hairui Wu, MD; Shun He, MD
Competition Sponsor: Chinese Academy of Medical Sciences
Awardee Year: 2024
Screening and early diagnosis and treatment of gastrointestinal malignant tumors are key components of China’s strategy to shift the focus of cancer prevention and treatment. Currently, endoscopic submucosal dissection (ESD) has become a significant option for treating early gastrointestinal tumors and precancerous lesions. Although ESD is considered a “super minimally invasive” treatment, studies indicate that it still has a certain rate of adverse events, particularly delayed postoperative bleeding, which can occur in 2.2%-11% of cases. As the nation gradually enters an aging society, the issues of high delayed bleeding probability among elderly patients on long-term anticoagulants have become increasingly serious. There is currently a lack of ideal clinical strategies to address this.
This study aims to develop a novel endoscopic hand suturing technique (EHS) and corresponding surgical instruments and materials, which can be used for the complete closure of larger mucosal defects after ESD, fundamentally addressing delayed bleeding and perforation problems in elderly high-risk patients. Preliminary studies abroad have confirmed the feasibility and safety of using EHS for closing gastric ESD defects; however, there are no multicenter clinical data on using EHS to close gastrointestinal mucosal defects in China.This research will employ the EHS technique to close gastrointestinal wounds post-ESD and will conduct a multicenter study to validate the success rate and lasting closure effects of the EHS technique, assessing its safety and reliability while further developing, improving, and upgrading the endoscopic suturing system.