Catalyst Awardee

Project Description

Development of Neuroprotective System Based on Selective Hypothermia for Brain Injury

Ming Li, PhD | Xuanwu Hospital and Beijing Institute for Brain Disorders, Capital Medical University;  Xunming Ji, MD, PhD; Miaowen Jiang, PhD; Zhichen Yin, PhD
Competition Sponsor:
 Chinese Academy of Medical Sciences
Awardee Year: 2023

Acute Ischemic stroke (AIS) has high mortality and disability rate. Reperfusion injury occurs after recanalization of blood vessels and there are no effective neuroprotective drugs, which lead to poor clinical outcomes after intravenous thrombolysis and mechanical thrombus removal. Mild hypothermia treatment is currently the most promising neuroprotective method, while whole body hypothermia is likely to cause side effects including chills, selective cold saline infusion hypothermia is likely to cause hemolysis and increase intracranial pressure, and it is difficult to accurately control temperature during a long time, and it is not possible to establish a standard hypothermia treatment plan for AIS patient, which has limited the application and promotion of this technology. Therefore, the research of brain disease and neuroscience requires a fast, accurate, safe and effective low-temperature brain protection device urgently. This project combines intravascular hypothermia technology with autologous blood transfusion hypothermia technology to develop a set of neuroprotection systems based on selective autologous blood hypothermia for brain injury, including the design of crucial parts such as stable flow rate and small flow magnetically driven centrifugal blood pump, miniaturized heat exchange oxygenation system, hypothermia-oriented intervention catheter, surface modification of the tubes used for circulation system and multi-parameter physiological monitor technology. The safety and effectiveness of the whole system will be verified by AIS animal model study. The hypothermia neuroprotective system will break through the technical bottleneck of the clinical application of hypothermia brain protection, offer a new tool for hypothermia neuroprotection research in brain disease and neuroscience.

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