Catalyst Awardee

Project Description

Establishment of Low-dose Piecewise CT Technique and Development of AI 3D Reconstruction Measurement Software for Measuring Rotational Force Line of Lower Extremity in Patients with Osteoarthritis

Zhenpeng Guan, MD | Peking University Shougang Hospital; Bin Zhang, MD; Chong Tang, MD;Keshi Zhang, MD;Zhe Xue, MD
Competition Sponsor:
 Chinese Academy of Medical Sciences
Awardee Year: 2023

Knee osteoarthritis (OA) has become a significant impact on the elderly health problems in the quality of life, its pathogenesis is complicated and interaction, the biomechanical factors that lower limbs osseous force line deformity is academia as one of the important risk factors. Coronal and sagittal force lines can be measured by full-length X-ray of lower limbs with low radiation dose (pure/lateral). However, in order to accurately measure the rotational force line of lower limbs, it must be measured by full-length CT scan of lower limbs with high radiation dose. This examination is often rejected by patients in clinical practice because of its excessive dose harm beyond the conventional radiation range of human body. There is no imaging sample bank for bone markers of lower limbs, and how to ensure the accuracy of CT imaging measurement data in patients with the lowest radiation dose is the focus of orthopedic and imaging doctors.
Based on this, the research team intends to establish a low-dose segmentary CT technique for measuring the rotational force line of lower extremity in patients with osteoarthritis. At the same time, AI-assisted CT scan 3D reconstruction bone marker measurement software was developed. We want to achieve the following goals :(1) to find the minimum radiation dose for patients that can measure accurate data of rotational bone markers of lower limbs; (2) With the aid of AI, a sample database of bone markers of lower limbs was established and fitted to obtain the gold standard of bone markers.

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