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Winners

Elucidating Mechanisms Through Which the Gut Microbiome Can Be Optimized Across the Human Lifespan

Catalyst Awardee
Nathan D. Price, PhD, Institute for Systems Biology; Sean Gibbons, PhD, Institute for Systems Biology; Leroy Hood, MD, PhD, Institute for Systems Biology and Providence St. Joseph Health; and Eric…
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Catalyst Awardee

Genetic Regulation of Exceptional Longevity in Rockfishes

Stephen Treaster, PhD, Boston Children’s Hospital and Harvard Medical School
Competition Sponsor: National Academy of Medicine Rockfishes (Sebastes genus), with nearly twenty-fold variation in longevity, are an untapped source of natural experiments in modulating, and resisting, the deleterious effects of age. The longest-lived can maintain health and function for over…
Catalyst Awardee

Halting Inflammaging Through Skin Barrier Restoration

Katrina Abuabara, MD, MA, MSCE, University of California, San Francisco (UCSF), and University of California, Berkeley; Timothy Berger, MD, UCSF; Steven Cummings, MD, San Francisco Coordinating Center and UCSF; Theodora Mauro, MD, UCSF and Veterans Administration Health Care System; and Charles E. McCulloch, PhD, UCSF Competition Sponsor: U.S. National Academy…
Catalyst Awardee

Investigating the Mechanisms of Age Dependent Decline in the Immunosurveillance of Senescent Cells by Natural Killer Cells

Amit Sharma, Ph.D., SENS Research Foundation; and Judith Campisi, Ph.D., Buck Institute
Competition Sponsor: National Academy of Medicine Senescent cells are characterized by an irreversible arrest of the cell cycle and secrete a milieu of pro-inflammatory cytokines, chemokines, and growth factors collectively referred to as the Senescence-Associated Secretory Phenotype (SASP)…
Catalyst Awardee

Investigating the Role of Intestinal Alkaline Phosphatase in the Aging-Associated Changes in Gut Barrier and Microbiome Using a Novel Microfluidic Intestine-on-Chip Model

Vidisha Mohad, PhD, Richard Hodin, MD, and Nima Saedi, PhD, Massachusetts General Hospital and Harvard Medical School Competition Sponsor: U.S. National Academy of Medicine Aging increases the vulnerability to many gastrointestinal diseases and is associated with the chronic inflammation, referred to as inflammaging. Aging- associated alteration in the microbiota has…
Catalyst Awardee

Nanocatalysis for the Improvement of Human Healthspan and Lifespan

Karen Ho, PhD, Clene Nanomedicine Inc.
Competition Sponsor: National Academy of Medicine The remarkable property of metal-based nanoparticles to efficiently catalyze chemical reactions has been recognized by the manufacturing industry, where there is growing interest in nanocatalysts as highly active, ‘green alternatives’ that enhance various chemical reactions. However, nanocatalysts have…
Catalyst Awardee

Paradigm Shift in the Molecular Transport to Brain Through the Direct Central Nerve-Innervation Based Retrograde Axonal Transport of Craniofacial Tissue Exosomes (RATCE)

Shigemi Ishikawa-Nagai, DMD, PhD, MSD, Harvard School of Dental Medicine; John da Silva, DMD, MPH, ScM, Harvard School of Dental Medicine; Albert Galaburda, MD, Harvard Medical School and Beth Israel Deaconess Medical Center; and Masazumi Nagai, DMD, PhD, Harvard School of Dental Medicine Competition Sponsor: U.S. National Academy of Medicine…
Catalyst Awardee

Resilient Brains: New Insights for Healthy Brain Aging

Michael McConnell, PhD, Lieber Institute for Brain Development; Daniel R. Weinberger, MD, Lieber Institute for Brain Development and Johns Hopkins University School of Medicine; and Thomas M. Hyde, MD, PhD, Lieber Institute for Brain Development and Johns Hopkins University School of Medicine Competition Sponsor: National Academy of Medicine Healthy lifestyle…
Catalyst Awardee

Retinal Imaging for Diagnosis of Aging-Related Brain Disorders

Alessandro Biffi, MD, Massachusetts General Hospital, Harvard University Medical School; Elena Z. Biffi, OD, MSc, New England College of Optometry; and Michael G. Morley, MD, ScM, Ophthalmic Consultants of Boston, Massachusetts Eye and Ear Infirmary, Harvard Medical School Competition Sponsor: National Academy of Medicine Vascular and degenerative brain disorders, such…

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