Winners Archive - Page 44 of 72 - healthylongevitychallenge.org

No autograft: Bone regeneration using carbonate apatite bone replacement

Nakashima Yasuharu, PhD; Ishikawa Kunio, PhD Competition Sponsor: Japan Agency for Medical Research and Development Carbonate apatite honeycomb (CO3Ap HC) arterial bone is the first 100% chemically pure artificial bone…

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Catalyst Awardee

Compounds that suppress the aging process through selective autophagy

Arimoto Hirokazu, PhD Competition Sponsor: Japan Agency for Medical Research and Development Autophagy is a major degradation system in cells. Best known is its ability to degrade existing proteins into amino acids during starvation. Autophagy also plays a vital role in the protection of the human body by removing invading…

Catalyst Awardee

Elucidation of the mechanism of autophagy driven by liquid-liquid phase separation

Fujioka Yuko, PhD Competition Sponsor: Japan Agency for Medical Research and Development Life science has entered a new phase to reconsider various phenomena, including autophagy, after discovery of liquid-liquid phase separation in cells. Autophagy is a major intracellular proteolysis pathway and plays an important role in proteostasis, which is essential…

Catalyst Awardee

The mechanisms of lifespan regulation by dietary manipulation

Obata Fumiaki, PhD Competition Sponsor: Japan Agency for Medical Research and Development Almost all animals, including humans, develop into adults and eventually age over time. As an environmental factor, dietary intake is essential throughout life. Diet contributes to metabolic and physiological homeostasis via nutrition, the composition of which is modulated…

Catalyst Awardee

The mechanism for the functional decline of aged neurons by comprehensive analysis of chromatin structure

Kishi Yusuke, PhD Competition Sponsor: Japan Agency for Medical Research and Development Prevention or restoration of the decline in memory associated with aging is one of the most important issues for healthy aging. In the brain, which controls memory, neurons are responsible for processing information, and the function, or potential,…

Catalyst Awardee

Clarifying the origins and very early processes of aging in tissue

Susaki Etsuo A., PhD Competition Sponsor: Japan Agency for Medical Research and Development Clarifying the origin and progression mechanism of aging inside tissue is the most fundamental and vital question in aging research. However, the rareness of such very early aging foci has prevented the identification and investigation of mechanisms…

Catalyst Awardee

A better prediction of onset-risk and onset-age using personal genomes

Morishita Shinichi, PhD Competition Sponsor: Japan Agency for Medical Research and Development The risk of getting a disease and the age of onset vary from person to person. If we can predict the risk and age of onset of disease for each individual, we can take preventive measures in advance…

Catalyst Awardee

Patch-type muscle sensing device for early detection of Frailty

Takei Yusuke, PhD Competition Sponsor: Japan Agency for Medical Research and Development We propose a patch-type sensor for early detection of frailty, which evaluates muscle quality (muscle mass, muscle strength, muscle fatigue, muscle contraction speed) from a mechanomyogram generated when muscles are contracted by electrical stimulation. This sensor is expected…

Catalyst Awardee

The mechanism of developing dementia through age-related metabolic change

Tonoki Ayako, PhD Competition Sponsor: Japan Agency for Medical Research and Development In a super-aging society, an increase in dementia patients is one of the social problems to be solved. Dysregulation of insulin signal associated with diabetes and obesity is known as one of the causes of increasing the risk…

Catalyst Awardee

Antisense RNA treatment against myotonic dystrophy

Beatriz Llamusí, MsC, PhD; Ruben Artero, MsC, PhD; Pedro Fernández, MsC, PhD; Sheila Soriano, MsC; Marc Carrscosa Competition Sponsor: EIT Health of the European Union ARTHEx is developing an advanced RNA therapy for myotonic dystrophy type 1 (DM1) based on a portfolio of patent-protected antimiRs. These antimiRs act as long-acting…

Winners

No autograft: Bone regeneration using carbonate apatite bone replacement

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