Catalyst Awardee

Project Description

Quantitative measurement of brain state and neurofeedback intervention techniques for the treatment of perioperative neurocognitive disorders in elderly patients

Hui Zheng, PhD, MD | National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College; Yibing Wu, B.E.; Jie Yu, PhD, MD; Cheng Ni, PhD, MD; Yongfeng Cheng, B.E.; Wenyue Xu, M.A.; Huaqing Chu, MD; Qi Hou, PhD, MD
Competition Sponsor: Chinese Academy of Medical Sciences
Awardee Year: 2022

The incidence of perioperative neurocognitive disorders (PND) in elderly surgical patients are as high as 40%. PND is closely related to the decline of postoperative quality of life, long-term cognitive impairment and increased one-year mortality after surgery. Current study and operation consider neuropsychological testing as the golden standard for the diagnosis of PND. However, results of such testing are often heavily dependent on factors such as types and judgment criterions for the assessment, and influences of aforementioned factors are magnified on elderly patients that have poor basic cognitive functions and compliance. Therefore, a rapid and objective test that quantitatively assess the brain status of such patients is urgently needed. In addition, there lacks clinical interventions that provide effective prevention or treatment for PND. EEG signals can reflect the comprehensive electrical activity of neurons in the cerebral cortex, and contain a large amount of human physiological, psychological and disease information that can assist the diagnosis and treatment of neurological diseases. With the continuous development of bioelectricity acquisition technology and artificial intelligence technology, the quantitative assessment of brain functional/emotional state and the data-guided brain health promotion training is in a technologically-ready state. Our project combined brain state quantification and neurofeedback training system to realize real time assessment and active intervention of perioperative brain function and status in elderly patients. Our study aims to achieve an integrated solution for the evaluation and improvement of perioperative brain state of elderly patients, reduce the incidence of PND, and provide insights for PND prevention and treatment.


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