Catalyst Awardee

Project Description

Randomized Control Trial for Dementia Prevention by Multimodal Interventions

Hidenori Arai, PhD, M.D. | National Center for Geriatrics and Gerontology; Takashi Sakurai, M.D., PhD | National Center for Geriatrics and Gerontology; Yoshinori Fujiwara, M.D., PhD | Tokyo Metropolitan Institute of Gerontology; Masafumi Kuzuya, M.D., PhD | Nagoya University; Hajime Takechi, MD, PhD | Fujita Health University
Nagoya City University
Competition Sponsor:
 Japan Agency for Medical Research and Development
Awardee Year: 2020

There is little evidence in Japan about what interventions may be effective for preventing dementia. Therefore, we plan to build solid evidence in Japan. In this study, the effectiveness of multimodal intervention programs (exercise, nutrition, cognitive training, lifestyle-related disease management) for high-risk older people for dementia will be addressed toward the social implementation of multimodal intervention programs by local governments and companies in the future. This is a multicenter randomized controlled clinical trial. The study results will be innovative in a sense of linking to social implementation, which can lead to a prolonged mental, physical, and social healthy life expectancy of older people. By making use of biomarkers and imaging, it is innovative to gain access to mechanisms related to cognitive improvement. It is expected that the effects of interventions on cognitive function as well as the effect on frailty will be shown, indicating the extension of the healthy life expectancy.

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View this project poster, first displayed at the 2021 Global Innovator Summit.

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