Catalyst Awardee

Project Description

Research and Development of Bioactive and Antibiotic Spinal Bone Cement Products

Zhang Miaozi, PhD

Competition Sponsor: Chinese Academy of Medical Sciences

PMMA bone cements are widely used in percutaneous vertebroplasty and kyphoplasty surgeries for the treatment of osteoporotic vertebral compression fractures. However, currently available PMMA bone cements cannot form osseointegration with the host bone tissue because they are bioinert, nor can they prevent or cure infections. This project will develop a series of spinal bone cement products with bioactivity and/or antibacterial properties, and provide total product solutions with patient-specific instruments. Project activities include determining the types, combinations and dosages of antibiotics and bioactive agents, investigating the interactions among antibiotic drugs, bioactive agents and cement materials, determining the best material system for the novel cement products; and developing innovative processes and technologies to achieve mass production of cement products. A series of pre-clinical bench performance tests, long-term biocompatibility tests, and in vitro and in vivo functional tests will be conducted to complete product design verification and validation along with relevant research reports.

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