Catalyst Awardee

Project Description

Risk prediction and scientific treatment strategy for atherectomy in colorectal cancer with thermofluidic multi-field bionic simulation intervention

Xu Qian, PhD |University of Science and Technology Beijing; Tang Danian, PhD; Cheng Shikun, PhD; Cui Jian, PhD; Zhang Hui, PhD; Zhang Sizong, PhD; Feng Junxiao, PhD; Xu Wenrui, PhD; Zhao Zhinan, ME; Shi Kejian, ME; Zhong Liqiong, BE; Yang Gang, BE; Zhang Xinyi, BE; Liu Dinghai, BE; Shen Meng, BE; Zhu Lidong, BE; Chen Xingli, BE; Zheng Qiang, BE; Fan Huanbao, BE 
Competition Sponsor: Chinese Academy of Medical Sciences
Awardee Year: 2022

While colorectal cancer surgery is removed, the lymph nodes of the blood vessels need to be completely cleaned. Individualized characteristics such as lymph node distribution and tumor dominance of the intestinal tube will lead to the difference in diagnosis and treatment planning. Especially for elderly patients with poor basic conditions and diseases, they need to focus on planning and ligation plans to ensure intestinal blood supply to the anastomotic mouth, and prevent postoperative complications such as leakage and thrombosis.This project focuses on the mechanism of coupling of blood and blood vessels in the surgical environment/human temperature characteristics.A simulation model of multi-field coupling of fluid-thermal-solid in the colorectal blood supply system was established, which is used to simulate the planning of clinical surgery planning, risk assessment and postoperative transfer assessment. Before surgery, this project formulates the left/right half colon blood transport system model according to human characteristics parameters, mapping clinical symptoms, quantitatively portraying the blood supply system transportation mechanism, and clarifying the intestinal wall to support the vascular resection scheme. After surgery, the actual anastomotic blood flow of the left/right hemicolectomy patients is to be observed using fluorescent markers of the anastomotic blood supply, Doppler ultrasound blood flow monitoring and angiography, and the model is to be compared and analyzed with the predicted results and adjusted to provide scientific postoperative assessment and clinical treatment guidance to help patients recover efficiently.


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