Catalyst Awardee

Project Description

Role of the Hypothalamus in Mammalian Aging/Longevity Through the Regulation of sleep Quality

Akiko Satoh, Ph.D. | National Center for Geriatrics and Gerontology
Competition Sponsor: Japan Agency for Medical Research and Development
Awardee Year: 2020

This study aims to elucidate the physiological function of PRDM13-positive neurons in the dorsomedial hypothalamus, and the molecular mechanisms by which PRDM13-positive neurons regulate sleep quality, and systemic phenomena sequentially occurring with age. In the future, we will evaluate whether modulation of PRDM13-positive neurons promotes beneficial effects in systemic aging and longevity, and will develop applicable interventions. Our proposed idea is a novel concept proving that age-associated systemic phenomena is initiated and progressed by a decline of sleep quality. In addition, this proposed research will open a novel approach against not only aging itself, but also dysfunctions of sleep, which is a common issue in elderly, leading to improvements in the quality of their life. Furthermore, targeting the early stage of age-associated sleep alteration would prevent several age-associated disorders that are known to have sleep problems as a risk factor, and ultimately contribute to extended health lifespan.

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