Lingfeng Meng, PhD | Beijing Hospital; Yaoguang Zhang, MD; Minggxiao Wu, MD; Zhipeng Zhang, MD; Jinfu Wang, MD; Wei Zhang, MD; Xiaodong Liu, MD.
Competition Sponsor: Chinese Academy of Medical Sciences
Awardee Year: 2023
Urinary incontinence refers to any involuntary urine leakage, which seriously affects the daily life and psychological state of patients. Artificial urethral sphincter (AUS) implantation has become the gold standard for treatment of moderate to severe stress urinary incontinence.In principle, AUS implantation, like other anti-incontinence procedures, are designed to increase urethral resistance and thus achieve urinary control. At present, it is considered that the cuff with appropriate size is the key to achieve urinary control, but there is no standardized guide for cuff size selection in clinical practice, and the selection of cuff size during surgery mainly depends on the measured periurethral diameter of the patient. The cuff size increases / decreases in the unit of 0.5cm, and it is often encountered in the actual clinical work that the measured periurethral diameter of patients does not meet the integer multiple of 0.5cm. In this case, no consensus has been reached on the selection of slightly larger / smaller cuff.Therefore, the purpose of this study is to explore the scope of safe urinary pressure of the AUS device, and to guide the selection of the cuff during AUS implantation by measuring the pressure provided to the urethra by the AUS device. In the later stage, a standardized and feasible system based on intraoperative urethral pressure profilometry will be formed to guide treatment, efficacy evaluation and predict complications, and the application and promotion of a new evaluation method represented by intraoperative urethral pressure profilometry was completed.