Catalyst Awardee

Project Description

Throat flora as a predictive marker of hereditary angioedema and its mechanism

Xue Wang, MD | Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences;Yuxiang Zhi, MD; Nan Zhou, BS; Yisen Yang, BS; Yaoyu Hu, BS; Shuanzheng Zhao, BS
Competition Sponsor:
 Chinese Academy of Medical Sciences
Awardee Year: 2023

Hereditary angioedema (HAE) is a rare, life-threatening autosomal dominant disorder characterized by recurrent, unpredictable episodes of skin and mucosal swelling. Asphyxia due to laryngeal edema is a common cause of death in patients. Previous studies by our team found that dysbiosis of the throat flora is associated with episodes of laryngeal edema, but the causal relationship is unclear, and the mechanism is unknown. Based on the established HAE prospective cohort, this study will elucidate the causal relationship between throat flora dysbiosis and laryngeal edema episodes. In addition, this study will explore the mechanism of laryngeal flora changes causing edema based on an animal model of HAE. The study will build an early warning model of acute laryngeal edema based on throat flora to assist physicians in identifying active patients and adjusting clinical interventions in a timely manner, which will provide new solutions to improve the quality of life and ensure the safety of HAE patients.

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